COVID-19-related headache and innate immune response – a narrative reviewReview Published on 2023-01-012023-07-09 Journal: Neurologia i neurochirurgia polska [Category] COVID19(2023년), [키워드] IFN IL-1β IL-6 innate immune response Pain. SARS-CoV-2 TLR-7 TNF [DOI] 10.5603/PJNNS.a2022.0049 PMC 바로가기 [Article Type] Review
Interleukin-18 and COVID-19Original Paper Published on 2022-12-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Analysis applied association conducted Coronavirus Disease (COVID)-19 COVID-19 cytokine estimate Evolutionary biology experimental design Exploratory analysis Genetic Genome-wide association study genome-wide significant hospitalised IFN Immunity interferon interferon gamma Interleukin-18 investigated less liberal lower risk Mendelian randomisation Odds ratio precursor predicted predictor predictors Prevent randomisation severe COVID-19 severity Standard deviation vulnerability was related with COVID-19 [DOI] 10.1017/S0950268821002636 PMC 바로가기 [Article Type] Original Paper
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines pro-inflammatory cytokines. Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagyArticle Published on 2022-11-012023-07-09 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] autophagy. COVID-19 IFN ORF10 SARS-CoV-2 STING [DOI] 10.1002/jmv.27965 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cellsArticle Published on 2022-10-282023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] IFN Immunity MicroRNAs SARS-CoV-2 virus-derived small RNAs. [DOI] 10.3389/fimmu.2022.1008084 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기